Differential Effects of Paromomycin on Ribosomes ofLeishmania mexicanaand Mammalian Cells
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چکیده
منابع مشابه
Differential effects of paromomycin on ribosomes of Leishmania mexicana and mammalian cells.
Paromomycin, an aminoglycoside antibiotic having low mammalian cell toxicity, is one of the drugs currently used in the chemotherapy of cutaneous and visceral leishmaniasis. In order to understand the mode of action of this antibiotic at the molecular level, we have investigated the effects of paromomycin on protein synthesis in Leishmania and its mammalian hosts. We were able to demonstrate th...
متن کاملDifferential effects of paromomycin on ribosomes of Leishmania 4 mexicana and mammalian cells . 5 6
6 Marisa M. Fernández 1 , Emilio L. Malchiodi 1 , and Israel D. Algranati 2 * 7 8 9 Cátedra de Inmunología and Instituto de Estudios de la Inmunidad Humoral (IDEHU), 10 CONICET-UBA, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, 1 11 and Fundación Instituto Leloir, Patricias Argentinas 435, 1405 Buenos Aires, Argentina 2 12 13 Running title: Paromomycin effect on Leishmania rib...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 2010
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.00506-10